Characterization of a plasmid coding for resistance to broad-spectrum cephalosporins in Salmonella typhimurium.

A. Garbarg-Chenon (1) , H. Vu Thien , R. Labia , H. Ben-Yaghlane , V. Godard (2) , P. Deny , F. Bricout , J. C. Nicolas

1 UPMC - Université Pierre et Marie Curie - Paris 6
2 LGENS - Laboratoire de géologie de l'ENS

Five strains of Salmonella typhimurium isolated from faeces of infants hospitalized at Trousseau Hospital in Paris have been found to be resistant to third-generation cephalosporins. This resistance is by a transferable plasmid-mediated mechanism. The beta-lactamase gene which encodes for an enzyme similar to SHV-2 has been cloned into plasmid pBR322 and expressed in Escherichia coli RR1.

Domaines: Chimie organique

A. Garbarg-Chenon, H. Vu Thien, R. Labia, H. Ben-Yaghlane, V. Godard, et al.. Characterization of a plasmid coding for resistance to broad-spectrum cephalosporins in Salmonella typhimurium.. Drugs Under Experimental and Clinical Research, 1989, 15 ((4)), pp.145-50. ⟨hal-00814688⟩