Quantitative assessment of myocardial viscoelastic properties using shear wave imaging

Abstract : Cardiac pathologies are often characterized by a significant change of myocardial stiffness, re-organization of muscle fiber structure, and the accompanying dysfunction, all of which remain challenging to be quantitatively assessed in vivo. The approach developed in this work is based on Shear Wave Imaging (SWI) a technique developed at the Langevin institute that provides real-time mapping of soft tissues viscoelastic properties. The technique relies on two successive steps: first, a shear wave is remotely induced in the myocardium using the acoustic radiation force of a focused beam, and second, the shear wave propagation is imaged using ultrafast imaging (10,000 frames per seconds). The shear modulus is derived from the shear wave speed. SWI is applied to the evaluation of myocardial stiffness on animal models of cardiomyopathy. The dynamics of change in shear modulus during the cardiac cycle is measured and the relationship between the viscoelastic properties and physiological parameters such as contractility or pathologies such as infarction is investigated. Finally, an imaging technique of the myocardial fiber orientation is developed by exploiting the anisotropy of shear wave propagation. This technique can map the complex distribution of muscle fibers in the myocardium and is compared to MR diffusion tensor imaging.
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Submitted on : Monday, April 23, 2012 - 10:00:00 AM
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Mathieu Pernot, Mathieu Couade, Wei-Ning Lee, Mathias Fink, Mickaël Tanter. Quantitative assessment of myocardial viscoelastic properties using shear wave imaging. Acoustics 2012, Apr 2012, Nantes, France. ⟨hal-00810876⟩



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