Phosphine-free palladium-catalyzed direct arylation of imidazo[1,2-a]pyridines with aryl bromides at low catalyst loading.

Hai Yan Fu (1) , Lu Chen (2) , Henri Doucet (2)

1 Sichuan University
2 ISCR - Institut des Sciences Chimiques de Rennes

Ligand-free Pd(OAc)(2) was found to catalyze very efficiently the direct arylation of imidazo[1,2-a]pyridines at C3 under very low catalyst concentration. The reaction can be performed employing as little as 0.1-0.01 mol % catalyst with electron-deficient and some electron-excessive aryl bromides.

Domaines: Catalyse

Hai Yan Fu, Lu Chen, Henri Doucet. Phosphine-free palladium-catalyzed direct arylation of imidazo[1,2-a]pyridines with aryl bromides at low catalyst loading.. Journal of Organic Chemistry, 2012, 77 (9), pp.4473-8. ⟨10.1021/jo300528b⟩. ⟨hal-00805251⟩