Regio- and stereoselective syntheses of piperidine derivatives via ruthenium-catalyzed coupling of propargylic amides and allylic alcohols.
Résumé
Intermolecular selective coupling of linear allylic alcohols and propargylic amides occurs in the presence of a catalytic amount of the cationic ruthenium complex [Cp*Ru(NCCH(3))(3)]PF(6) followed by condensation to generate six-membered cyclic enamides or hemiaminal ethers with water as the only side product.