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Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b.

Abstract : Serotonin is a monoamine neurotransmitter that is involved in numerous physiological functions and its dysregulation is implicated in various psychiatric diseases. In all non-placental vertebrates, serotoninergic (5-HT) neurons are present in several regions of the brain, including the hypothalamus. In placental mammals, however, 5-HT neurons are located in the raphe nuclei only. In all species, though, 5-HT neurons constitute a functionally and molecularly heterogeneous population. How the non-raphe 5-HT populations are developmentally encoded is unknown. Using the zebrafish model we show that, in contrast to the raphe populations, hypothalamic 5-HT neurons are generated independently of the ETS-domain transcription factor Pet1 (Fev). By applying a combination of pharmacological tools and gene knockdown and/or overexpression experiments, we demonstrate that Fgf signalling acts via another ETS-domain transcription factor, Etv5b (Erm), to induce hypothalamic 5-HT neurons. We provide evidence that Etv5b exerts its effects by regulating cell cycle parameters in 5-HT progenitors. Our results highlight a novel role for Etv5b in neuronal development and provide support for the existence of a developmental heterogeneity among 5-HT neurons in their requirement for ETS-domain transcription factors.
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https://hal.archives-ouvertes.fr/hal-00781231
Contributor : Alain Perignon Connect in order to contact the contributor
Submitted on : Friday, January 25, 2013 - 4:55:35 PM
Last modification on : Wednesday, February 24, 2021 - 12:32:02 PM

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Adriana Bosco, Charlotte Bureau, Pierre Affaticati, Patricia Gaspar, Laure Bally-Cuif, et al.. Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b.. Development (Cambridge, England), Company of Biologists, 2013, 140 (2), pp.372-84. ⟨10.1242/dev.089094⟩. ⟨hal-00781231⟩

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