Association of a Love wave sensor to thin film molecularly imprinted polymers for nucleosides analogs detection

Abstract : The overall objective of this work is to develop and validate a quantitative, non-invasive therapeutic tool to detect selected urinary modified nucleosides as biomarkers of colorectal cancer chemotherapy and to monitor in fine the efficiency of the chemotherapy. Our methodology takes the advantage of high sensitivity of acoustic biosensor combined with high selectivity and robustness of thin molecularly imprinted polymer (MIP) film. In this paper we present a process based on a thin film of a MIP of adenosine 5'-monophosphate (AMP) coating on the sensor surface which is compatible with the acoustic wave propagation. Detection tests of AMP have been performed in aqueous media. The sensor response was recorded in terms of synchronous frequency and total insertion losses after both steps: extraction from, rebinding by the MIP layer. A frequency decrease of 6.875 Hz was recorded for 25μg/mL AMP concentration.
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https://hal.archives-ouvertes.fr/hal-00772051
Contributor : Corinne Dejous <>
Submitted on : Wednesday, January 9, 2013 - 6:43:47 PM
Last modification on : Friday, June 14, 2019 - 6:31:06 PM

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Naïma Lebal, Hamida Hallil, Corinne Dejous, Aleksandra Kristulja, Raphaël Delépée, et al.. Association of a Love wave sensor to thin film molecularly imprinted polymers for nucleosides analogs detection. The IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS 2013), Apr 2013, Suzhou, China. pp.550-553, ⟨10.1109/NEMS.2013.6559790⟩. ⟨hal-00772051⟩

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