Prompt and slow electron-detachment-dissociation/electron-photodetachment-dissociation of a 21-mer Peptide.

Abstract : Electron detachment dissociation (EDD) and electron photodetachment dissociation (EPD) are relatively new dissociation methods that involve electron detachment followed by radical-driven dissociation from multiply deprotonated species. EDD yields prompt dissociation whereas only electron detachment is obtained by EPD; subsequent vibrational activation of the charge-reduced radical anion is required to obtain the product ions. Herein, the fragmentation patterns that were obtained by EDD and by vibrational activation of the charge-reduced radical anions that were produced through EDD or EPD (activated-EDD and activated-EPD) were compared. The observed differences were related to the dissociation kinetics and/or the contribution of electron-induced dissociation (EID). Time-resolved double-resonance experiments were performed to measure the dissociation rate constants of the EDD product ions. Differences in the formation kinetics were revealed between the classical EDD/EPD 'a(.) (i) /''x(j) complementary ions and some 'a(.) (i) /c(i) /'''z(.) (j) product ions, which were produced with slower dissociation rate constants, owing to the presence of specific neighbouring side chains. A new fragmentation pathway is proposed for the formation of the slow-kinetics 'a(.) (i) ions.
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Chemistry - A European Journal, Wiley-VCH Verlag, 2013, 19 (1), pp.350-7. 〈10.1002/chem.201202578〉
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https://hal.archives-ouvertes.fr/hal-00770793
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Soumis le : lundi 7 janvier 2013 - 15:03:53
Dernière modification le : jeudi 7 février 2019 - 17:43:22

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Marie Pérot-Taillandier, Séverine Zirah, Quentin Enjalbert, Rodolphe Antoine, Jérôme Lemoine, et al.. Prompt and slow electron-detachment-dissociation/electron-photodetachment-dissociation of a 21-mer Peptide.. Chemistry - A European Journal, Wiley-VCH Verlag, 2013, 19 (1), pp.350-7. 〈10.1002/chem.201202578〉. 〈hal-00770793〉

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