Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri.

Pierre-Marie Allard (1) , Pieter Leyssen , Marie-Thérèse Martin (1) , Mélanie Bourjot , Vincent Dumontet (1) , Cécilia Eydoux , Jean-Claude Guillemot , Bruno Canard , Cyril Poullain (1) , Françoise Guéritte (1) , Marc Litaudon (1)

1 ICSN - Institut de Chimie des Substances Naturelles

The chemical study of the bark and the wood of Trigonostemon cherrieri, a rare endemic plant of New Caledonia, led to the isolation of a series of highly oxygenated daphnane diterpenoid orthoesters (DDO) bearing an uncommon chlorinated moiety: trigocherrins A-F and trigocherriolides A-D. Herein, we describe the isolation and structure elucidation of the DDO (trigocherrins B-F and trigocherriolides A-D). We also report the antiviral activity of trigocherrins A, B and F (1, 2 and 6) and trigocherriolides A, B and C (7-9) against various emerging pathogens: chikungunya virus (CHIKV), Sindbis virus (SINV), Semliki forest virus (SFV) and dengue virus (DENV).

Domaines: Chimie organique

Pierre-Marie Allard, Pieter Leyssen, Marie-Thérèse Martin, Mélanie Bourjot, Vincent Dumontet, et al.. Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri.. Phytochemistry, 2012, 84, pp.160-8. ⟨10.1016/j.phytochem.2012.07.023⟩. ⟨hal-00769790⟩