Catalytic fluorination of dichloromethylbenzene by HF in liquid phase. Preparation of fluorinated building blocks

Alexandre Piou (1) , Stephane Celerier (1) , Sylvette Brunet (1)

1 LACCO - Laboratoire de catalyse en chimie organique

The selective fluorination by successive Cl/F exchanges of the dichloromethylbenzene, was studied in the presence of HF as the fluorinating agent. The influence of the presence of a catalyst or a basic solvent (such as dioxane, pyridine, tributylphosphate) in order to favour the fluorination was investigated. In mild conditions, (50 °C and after 1 h of reaction), the fluorination of the dichloromethylbenzene was observed and the polymerization reaction inhibited. The best results were obtained in the presence of the HF-dioxane system and antimony trifluoride as catalyst.

Domaines: Chimie

Alexandre Piou, Stephane Celerier, Sylvette Brunet. Catalytic fluorination of dichloromethylbenzene by HF in liquid phase. Preparation of fluorinated building blocks. Journal of Fluorine Chemistry, 2012, 134, pp.103-106. ⟨10.1016/j.jfluchem.2011.04.003⟩. ⟨hal-02183894⟩