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Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing.

Abstract : Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.
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https://hal.archives-ouvertes.fr/hal-00766336
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Submitted on : Tuesday, December 18, 2012 - 10:41:14 AM
Last modification on : Wednesday, December 1, 2021 - 11:18:31 AM

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Julien Colombani, Ditte S Andersen, Pierre Léopold. Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing.. Science, American Association for the Advancement of Science, 2012, 336 (6081), pp.582-5. ⟨10.1126/science.1216689⟩. ⟨hal-00766336⟩

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