Genetic polymorphisms and childhood acute lymphoblastic leukemia: GWAS of the ESCALE study (SFCE).

Laurent Orsi (1) , Jérémie Rudant , Audrey Bonaventure (1) , Stéphanie Goujon-Bellec (1) , Eve Corda , Tom Evans , Arnaud Petit , Yves Bertrand , Brigitte Nelken , Alain Robert , Gérard Michel (2) , Nicolas Sirvent (3) , Pascal Chastagner (4) , Stéphane Ducassou , Xavier Rialland , Denis Hémon , Elizabeth Milne , Rodney Scott (5, 6) , André Baruchel , Jacqueline Clavel (1)

1 Epidémiologie environnementale des cancers
2 TIMONE - Hôpital de la Timone [CHU - APHM]
3 Service de Pédiatrie, Unité d'Oncologie et Hématologie Pédiatrique
4 SIGRETO - Signalisation, Génomique et Recherche Translationnelle en Oncologie
5 Discipline of Medical Genetics, Faculty of Health
6 Hunter Medical Research Institute

Every year, acute lymphoblastic leukaemia (ALL) affects about 400 children aged <15 years in France,accounting for approximately 80% of the acute leukaemia (AL) cases. The heterogeneity of cell types is reflected in the heterogeneity of clinical presentation, prognosis and, possibly, risk factors.

Domaines: Cancer

Laurent Orsi, Jérémie Rudant, Audrey Bonaventure, Stéphanie Goujon-Bellec, Eve Corda, et al.. Genetic polymorphisms and childhood acute lymphoblastic leukemia: GWAS of the ESCALE study (SFCE).. Leukemia, 2012, 26 (12), pp.2561-2564. ⟨10.1038/leu.2012.148⟩. ⟨hal-00765662⟩