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Achieving high spatial resolution and high SNR in low-field MRI of hyperpolarised gases with Slow Low Angle SHot

Abstract : MRI of hyperpolarised gases is usually performed with fast data acquisition to achieve high spatial resolutions despite rapid diffusion-induced signal attenuation. We describe a double-cross k-space sampling scheme suitable for slow low angle shot (SLASH) acquisition and yielding an increased SNR. It consists of a series of anisotropic partial acquisitions with a reduced resolution in the read direction, which alleviates signal attenuation and still provides a high isotropic resolution. The advantages of SLASH imaging over conventional FLASH imaging are evaluated analytically, using numerical lattice calculations, and experimentally in phantom cells filled with hyperpolarised 3He-N2 gas mixtures. Low-field MRI is performed (here 2.7 mT), a necessary condition to obtain long T2* values in lungs for slow acquisition. Two additional benefits of the SLASH scheme over FLASH imaging have been demonstrated: it is less sensitive to the artefacts due to concomitant gradients and it allows measuring apparent diffusion coefficients for an extended range of times.
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https://hal.archives-ouvertes.fr/hal-00761896
Contributor : Pierre-Jean Nacher Connect in order to contact the contributor
Submitted on : Thursday, December 6, 2012 - 11:14:09 AM
Last modification on : Thursday, March 17, 2022 - 10:08:09 AM
Long-term archiving on: : Thursday, March 7, 2013 - 3:59:33 AM

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Kayum Safiullin, Cavin Talbot, Pierre-Jean Nacher. Achieving high spatial resolution and high SNR in low-field MRI of hyperpolarised gases with Slow Low Angle SHot. Journal of Magnetic Resonance, Elsevier, 2013, 227, pp.72-86. ⟨10.1016/j.jmr.2012.11.025⟩. ⟨hal-00761896⟩

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