System identification of the intrabrain tumoral uptake of multifunctional nanoparticles

Abstract : Recent developments on multifunctional nano-systems have opened new perspectives for tumor control by proposing new nano-actuators and nano-sensors in in vivo anti-cancer treatments. But the delivery control of these nano-agents into the cancer cells is one of the major factors that directly affect the efficiency of nanotherapies. In this study, we show that system identification methods (CONTSID Matlab toolbox), generally used in control engineering, can bring efficient solutions to help biologists to estimate crucial parameters of the nanoparticles pharmacokinetics from experimental data. The in vivo results presented herein clearly emphasize the relevance of these data-driven modeling approaches associated with magnetic resonance imaging.
Document type :
Conference papers
8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012, Aug 2012, Budapest, Hungary. pp.CDROM, 2012


https://hal.archives-ouvertes.fr/hal-00753965
Contributor : Thierry Bastogne <>
Submitted on : Tuesday, November 20, 2012 - 4:03:15 AM
Last modification on : Tuesday, September 22, 2015 - 1:12:44 AM

File

BMS_2012_JBT_nanoMRI_TB.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : hal-00753965, version 1

Collections

Citation

Jean-Baptiste Tylcz, Denise Bechet, Thierry Bastogne, Hugues Garnier, Muriel Barberi-Heyob. System identification of the intrabrain tumoral uptake of multifunctional nanoparticles. 8th IFAC Symposium on Biological and Medical Systems, IFAC BMS 2012, Aug 2012, Budapest, Hungary. pp.CDROM, 2012. <hal-00753965>

Export

Share

Metrics

Record views

188

Document downloads

79