Scanning electrochemical microscopy monitoring in microcantilever platforms

Sorin Munteanu 1 Sarra Gam-Derouich 1 Cécile Flammier 2 Yasmina Fedala 1 Catherine Combellas 1 Fabien Amiot 2 Frédéric Kanoufi 1
2 MECANIQUE APPLIQUEE
FEMTO-ST - Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174)
Abstract : The deflection of cantilever systems may be performed by an indirect electrochemical method that consists of measuring the local cantilever activity and deflection in a feedback generation-collection configuration of the SECM. This is illustrated during the electrochemically assisted adsorption of Br onto a gold-coated cantilever, either in its pristine state or previously coated with a thin organic barrier. It is further extended to the adsorption of an antibody in a heterogeneous immunoassay at an allergen-coated microcantilever platform. In both reactions, the cantilever deflection is qualitatively detected from the SECM tip current measurement and a quantitative estimate is obtained through modeling. This electro-analytical strategy provides an alternative approach to standard optical detection. It can overcome some limitations of the optical method by allowing electro-chemical characterization of nonconductive cantilevers and appropriate use for closed systems.
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Journal articles
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Submitted on : Monday, November 12, 2012 - 9:36:19 AM
Last modification on : Thursday, July 4, 2019 - 11:00:06 AM

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Sorin Munteanu, Sarra Gam-Derouich, Cécile Flammier, Yasmina Fedala, Catherine Combellas, et al.. Scanning electrochemical microscopy monitoring in microcantilever platforms. Analytical Chemistry, American Chemical Society, 2012, 84 (17), pp.7449-7455. ⟨10.1021/ac301502a⟩. ⟨hal-00750683⟩

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