Effect of baroreflex stimulation using phenylephrine injection on ST segment elevation and ventricular arrhythmia-inducibility in Brugada syndrome patients.

Abstract : AIMS: Patients affected by Brugada syndrome (BrS) are at risk of sudden cardiac death specifically at rest, when vagal tone is high. The aim of our study was to assess whether a phenylephrine injection, which provokes a baroreflex stimulation, could induce modification of the ST segment elevation and ventricular arrhythmias. METHODS AND RESULTS: Baroreflex test was performed with the administration of phenylephrine (2 microg/kg) to four highly symptomatic patients in a setting fully equipped for cardiac resuscitation. Phenylephrine injection induced a deep vagal stimulation with a decrease in the mean heart rate from 75 +/- 7 to 50 +/- 8 bpm and an increase in the mean systolic blood pressure from 141 +/- 14 to 204 +/- 46 mmHg. ST segment elevation was not modified and no ventricular arrhythmias were induced during the test. CONCLUSION: Although phenylephrine injection induced a major alpha-adrenergic vasoconstriction followed by an arterial baroreflex, this test failed to provoke ventricular arrhythmias or modification of the ST segment elevation in BrS patients.
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Submitted on : Friday, November 9, 2012 - 10:52:42 PM
Last modification on : Friday, April 5, 2019 - 9:22:02 AM

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Vincent Probst, Philipe Mabo, Frederic Sacher, Dominique Babuty, Jacques Mansourati, et al.. Effect of baroreflex stimulation using phenylephrine injection on ST segment elevation and ventricular arrhythmia-inducibility in Brugada syndrome patients.. EP-Europace, Oxford University Press (OUP): Policy B, 2009, 11 (3), pp.382-4. ⟨10.1093/europace/eun365⟩. ⟨hal-00750426⟩

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