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Journal articles
Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties.
Sohini Sanyal
1
Stéphane Egée
2
Guillaume Bouyer
2
Sylvie Perrot
3
Innocent Safeukui
3
Emmanuel Bischoff
4
Pierre Buffet
3, 5
Kirk W Deitsch
1
Odile Mercereau-Puijalon
3
Peter H David
3
Thomas J Templeton
1
Catherine Lavazec
3, 4
Sohini Sanyal 1
Author
Stéphane Egée 2
Author
Guillaume Bouyer 2
Author IdHAL : guillaume-bouyer ORCID : https://orcid.org/0000-0002-5808-0539
Sylvie Perrot 3
Author
Innocent Safeukui 3
Author
Emmanuel Bischoff 4
Author
Pierre Buffet 3, 5
Author
Kirk W Deitsch 1
Author
Odile Mercereau-Puijalon 3
Author
Peter H David 3
Author
Thomas J Templeton 1
Author
Catherine Lavazec 3, 4
Author
1
Department of Microbiology and Immunology (Weill Cornell Medical College, and the Weill Graduate School of Medical Sciences of Cornell University, New York - United States)
- Cornell University ( Ithaca, New York 14853 - United States)
2
MS - Mer et santé (Station biologique Place Georges Teissier - BP 74 29682 ROSCOFF CEDEX - France)
- SBR - Station biologique de Roscoff [Roscoff] (Place Georges Teissier - BP 74 29682 ROSCOFF CEDEX - France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : FR2424 (France)
- CNRS - Centre National de la Recherche Scientifique : FRE2775 (France)
- UPMC - Université Pierre et Marie Curie - Paris 6 : UMR7150 (4 place Jussieu - 75005 Paris - France)
3
Immunologie moléculaire des parasites (25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR2581 (France)
4
Génétique et Génomique des Insectes vecteurs (Département Parasites et Insectes vecteurs, 25-28, rue du docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : URA3012 (France)
5
Immunité et Infection (France)
- UPMC - Université Pierre et Marie Curie - Paris 6 (4 place Jussieu - 75005 Paris - France)
- IFR113 (France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U945 (101, rue de Tolbiac, 75013 Paris - France)
Abstract : Infection of erythrocytes with the human malaria parasite, Plasmodium falciparum, results in dramatic changes to the host cell structure and morphology. The predicted functional localization of the STEVOR proteins at the erythrocyte surface suggests that they may be involved in parasite-induced modifications of the erythrocyte membrane during parasite development. To address the biologic function of STEVOR proteins, we subjected a panel of stevor transgenic parasites and wild-type clonal lines exhibiting different expression levels for stevor genes to functional assays exploring parasite-induced modifications of the erythrocyte membrane. Using this approach, we show that stevor expression impacts deformability of the erythrocyte membrane. This process may facilitate parasite sequestration in deep tissue vasculature.
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Journal articles
Complete list of metadatas
https://hal.archives-ouvertes.fr/hal-00746749
Contributor : Sophie Paris <>
Submitted on : Monday, October 29, 2012 - 3:54:36 PM
Last modification on : Tuesday, December 8, 2020 - 3:39:00 AM
Contributor : Sophie Paris <>
Submitted on : Monday, October 29, 2012 - 3:54:36 PM
Last modification on : Tuesday, December 8, 2020 - 3:39:00 AM
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Identifiers
- HAL Id : hal-00746749, version 1
- DOI : 10.1182/blood-2011-08-370734
- PUBMED : 22106347
Collections
PASTEUR | UPMC | CNRS | SORBONNE-UNIVERSITE | SU-MEDECINE | SU-SCIENCES | FR2424 | LBI2M | SU-TI
Citation
Sohini Sanyal, Stéphane Egée, Guillaume Bouyer, Sylvie Perrot, Innocent Safeukui, et al.. Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties.. Blood, American Society of Hematology, 2012, 119 (2), pp.e1-8. ⟨10.1182/blood-2011-08-370734⟩. ⟨hal-00746749⟩
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