Pragmatic management of Panton-Valentine leukocidin-associated staphylococcal diseases

Y. Gillet (1) , O. Dumitrescu (2, 3) , A. Tristan (2, 3) , O. Dauwalder (2, 3) , E. Javouhey (1) , D. Floret (1) , F. Vandenesch (2, 3) , J. Etienne (2, 3) , G. Lina (2, 3)

1 Division of Pediatric Intensive Care
2 Centre National de Reference des Staphylocoques
3 INSERM U851

Panton-Valentine leukocidin (PVL)-producing is associated with a broad spectrum of diseases, ranging from common uncomplicated soft tissue infections to severe diseases such as complicated soft tissue infections, extensive bone and joint infections, and necrotizing pneumonia. Specialised management of infection based on the presence of PVL may not be required for mild infections, whereas it could be lifesaving in other settings. Moreover, most severe PVL diseases are recently identified entities and a 'gold standard' treatment from comparatives studies of different therapeutic options is lacking. Thus, recommendations are based on expert opinions, which are elaborated based on theory, in vitro data and analogies with other toxin-mediated diseases. In this review, we consider the potential need for specialised PVL-based management and, if required, which tools should be used to achieve optimal management.

Mots clés: Staphylococcus aureus; Panton-Valentine leukocidin; Treatment

Domaines: Microbiologie et Parasitologie

Y. Gillet, O. Dumitrescu, A. Tristan, O. Dauwalder, E. Javouhey, et al.. Pragmatic management of Panton-Valentine leukocidin-associated staphylococcal diseases. International Journal of Antimicrobial Agents, 2011, 38 (6), pp.457. ⟨10.1016/j.ijantimicag.2011.05.003⟩. ⟨hal-00746417⟩