Non-invasive long-term and real-time analysis of endocrine cells on micro-electrode arrays

Abstract : Non-invasive high-throughput and long-term monitoring of endocrine cells is important for drug research, phenotyping, tissue engineering and pre-transplantation quality control. Here we report a novel approach to obtain simultaneous long-term electrical recordings of different islet cell types using multi-electrode arrays. We implemented wavelet transforms to resolve the low signal/noise ratio inherent to these measurements and extracted on-line a signature specific of cell activity. The architecture employed allows multiplexing a large number of electrodes for high-throughput screening. This method should be of considerable advantage in endocrine research and may be extended to other excitable cells previously not accessible to the technique.
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Journal of Physiology, Wiley, 2011, 590 (5), pp.1085-1091
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Matthieu Raoux, Yannick Bornat, Adam Quotb, Bogdan Catargi, Sylvie Renaud, et al.. Non-invasive long-term and real-time analysis of endocrine cells on micro-electrode arrays. Journal of Physiology, Wiley, 2011, 590 (5), pp.1085-1091. 〈hal-00742984〉

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