Heterochromatin establishment in the context of genome-wide epigenetic reprogramming.

Aline V Probst (1) , Geneviève Almouzni (1)

1 DNPG - Dynamique nucléaire et plasticité du génome

Heterochromatin at pericentric satellites, characterized by a specific chromatin signature and chromocenter organization, is of paramount importance for genome function. Re-establishment of this organization after fertilization takes place in the context of genome-wide epigenetic reprogramming. We review how the asymmetry in histone variants and post-translational modifications between paternal and maternal genomes and their respective pericentric heterochromatin domains evolve during early cleavage stages in mouse. We draw a parallel between these data and the burst of pericentric satellite transcription that occurs concomitantly with the dynamic reorganization of the pericentric domains into chromocenters in two-cell stage embryos. Based on this new angle, we propose that a crucial developmental transition at the two-cell stage allows chromocenter formation by involving non-coding satellite transcripts to trigger specific chromatin changes.

Domaines: Biologie cellulaire

Aline V Probst, Geneviève Almouzni. Heterochromatin establishment in the context of genome-wide epigenetic reprogramming.. Trends in Genetics, 2011, 27 (5), pp.177-85. ⟨10.1016/j.tig.2011.02.002⟩. ⟨hal-00742753⟩