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Article Dans Une Revue Nano Letters Année : 2012

Intercellular carbon nanotube translocation assessed by flow cytometry imaging.

Résumé

The fate of carbon nanotubes in the organism is still controversial. Here, we propose a statistical high-throughput imaging method to localize and quantify functionalized multiwalled carbon nanotubes in cells. We give the first experimental evidence of an intercellular translocation of carbon nanotubes. This stress-induced longitudinal transfer of nanomaterials is mediated by cell-released microvesicles known as vectors for intercellular communication. This finding raises new critical issues for nanotoxicology, since carbon nanotubes could be disseminated by circulating extracellular cell-released vesicles and visiting several cells in the course of their passage into the organism.
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Dates et versions

hal-00741396 , version 1 (12-10-2012)

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Iris Marangon, Nicole Boggetto, Cécilia Ménard-Moyon, Enrica Venturelli, Marie-Lys Béoutis, et al.. Intercellular carbon nanotube translocation assessed by flow cytometry imaging.. Nano Letters, 2012, 12 (9), pp.4830-7. ⟨10.1021/nl302273p⟩. ⟨hal-00741396⟩
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