Biomechanical Assessment of the Individual Risk of Rupture of Cerebral Aneurysms: A Proof of Concept

Abstract : This study is a step towards a new biomechanical-based measurement of the patient specific risk of rupture of cerebral aneurysms. Following a previous exper- imental investigation suggesting a correlation between the risk of rupture and the material properties of cerebral aneurysms, fluid-structure interaction simulations are performed to compare the deformations of a patient-specific aneurysm when using degraded or undegraded materials. Results show that material properties have a major impact on the magnitude of systolic/diastolic aneurysmal volume variations along the cardiac cycle. Changes in terms of aneurysmal volume variations depend- ing on the tissue characteristics are shown to be measurable by medical imaging. A one-at-a-time data uncertainty analysis is also presented and shows the robustness of this result to input data uncertainties. The study thus suggests that aneurysmal volume variations may be used as the basis of a biomechanical index of rupture risk.
Complete list of metadatas

Cited literature [39 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-00737354
Contributor : François Gibier <>
Submitted on : Monday, October 1, 2012 - 3:28:38 PM
Last modification on : Wednesday, May 29, 2019 - 10:04:03 AM
Long-term archiving on : Wednesday, January 2, 2013 - 7:35:11 AM

File

Biomechanical_assessment_indiv...
Files produced by the author(s)

Identifiers

Citation

Mathieu Sanchez, Dominique Ambard, Vincent Costalat, Simon Mendez, Franck Jourdan, et al.. Biomechanical Assessment of the Individual Risk of Rupture of Cerebral Aneurysms: A Proof of Concept. Annals of Biomedical Engineering, Springer Verlag, 2012, 41 (1), pp.28-40. ⟨10.1007/s10439-012-0632-2⟩. ⟨hal-00737354⟩

Share

Metrics

Record views

276

Files downloads

243