Skip to Main content Skip to Navigation
Journal articles

Nonlocal regularization for active appearance model: Application to medial temporal lobe segmentation.

Abstract : The human medial temporal lobe (MTL) is an important part of the limbic system, and its substructures play key roles in learning, memory, and neurodegeneration. The MTL includes the hippocampus (HC), amygdala (AG), parahippocampal cortex (PHC), entorhinal cortex, and perirhinal cortex-structures that are complex in shape and have low between-structure intensity contrast, making them difficult to segment manually in magnetic resonance images. This article presents a new segmentation method that combines active appearance modeling and patch-based local refinement to automatically segment specific substructures of the MTL including HC, AG, PHC, and entorhinal/perirhinal cortex from MRI data. Appearance modeling, relying on eigend-ecomposition to analyze statistical variations in image intensity and shape information in study population, is used to capture global shape characteristics of each structure of interest with a generative model. Patch-based local refinement, using nonlocal means to compare the image local intensity properties, is applied to locally refine the segmentation results along the structure borders to improve structure delimitation. In this manner, nonlocal regularization and global shape constraints could allow more accurate segmentations of structures. Validation experiments against manually defined labels demonstrate that this new segmentation method is computationally efficient, robust, and accurate. In a leave-one-out validation on 54 normal young adults, the method yielded a mean Dice κ of 0.87 for the HC, 0.81 for the AG, 0.73 for the anterior parts of the parahippocampal gyrus (entorhinal and perirhinal cortex), and 0.73 for the posterior parahippocampal gyrus. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.
Complete list of metadatas

Cited literature [60 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-00736864
Contributor : Pierrick Coupé <>
Submitted on : Sunday, September 30, 2012 - 2:19:14 PM
Last modification on : Thursday, March 12, 2020 - 3:06:05 PM
Document(s) archivé(s) le : Friday, December 16, 2016 - 6:48:35 PM

File

Hu_HBM2012.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Shiyan Hu, Pierrick Coupé, Jens C Pruessner, D Louis Collins. Nonlocal regularization for active appearance model: Application to medial temporal lobe segmentation.. Human Brain Mapping, Wiley, 2012, epub ahead of print. ⟨10.1002/hbm.22183⟩. ⟨hal-00736864⟩

Share

Metrics

Record views

358

Files downloads

365