Efficient Syntheses of New Chromone- and Chromanequinoline Hybrids and their Aza-analogs

Abstract : Some novel chromone- and chromanequinoline hybrids and their aza-analogs were synthesized from 2-chloro- 3-quinolinecarboxaldehydes as starting materials. The cyclization of 2-hydroxychalcones in the presence of AcONa yielded chroman-4-ones, while, in the typical AFO conditions, the 2-corresponding quinolyl-3-hydroxyflavonols were obtained. These approaches were extended to 2-aminochalcones, which delivered the 3-hydroxy-2,3-dihydroquinolin- 4(1H)-one via an epoxy-ketone and 2-quinolyl-2,3-dihydroquinoline-4(1H)-one under microwave irradiation in the presence of silica gel impregnated with indium (III) chloride.
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Letters in Organic Chemistry, Bentham Science Publishers, 2011, 8 (6), pp.374-379. 〈10.2174/157017811796064494〉
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Soumis le : vendredi 28 septembre 2012 - 10:36:04
Dernière modification le : samedi 22 décembre 2018 - 19:23:16

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Abelmalek Bouraiou, Fabienne Berrée, Sofiane Bouacida, Bertrand Carboni, Abdelmadjid Debache, et al.. Efficient Syntheses of New Chromone- and Chromanequinoline Hybrids and their Aza-analogs. Letters in Organic Chemistry, Bentham Science Publishers, 2011, 8 (6), pp.374-379. 〈10.2174/157017811796064494〉. 〈hal-00736388〉

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