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Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy

Abstract : Hydrophobically modified magnetic nanoparticles (MNPs) were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formulation method provides a high loading of MNPs (up to 70 wt %) together with a good control over the sizes of the vesicles (100 - 400 nm). The deformation of the vesicle membrane under an applied magnetic field was evidenced by anisotropic SANS. These hybrid objects display contrast enhancement properties in Magnetic Resonance Imaging, a diagnostic method routinely used for three-dimensional and non-invasive scans of the human body. They can also be guided in a magnetic field gradient. The feasibility of drug release triggered by magnetic induction was evidenced using the anticancer drug doxorubicin (DOX), which is co-encapsulated in the membrane. Magnetic polymersomes are thus proposed as multimodal drug nanocarriers for bio-imaging and magneto-chemotherapy.
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https://hal.archives-ouvertes.fr/hal-00734562
Contributor : Olivier Sandre <>
Submitted on : Sunday, September 23, 2012 - 4:32:26 PM
Last modification on : Saturday, April 25, 2020 - 4:24:08 PM
Document(s) archivé(s) le : Monday, December 24, 2012 - 3:00:10 AM

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  • HAL Id : hal-00734562, version 1
  • ARXIV : 1209.5098

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Charles Sanson, Odile Diou, Julie Thevenot, Emmanuel Ibarboure, Alain Soum, et al.. Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy. LLB Highlights 2011, 2012, pp.48-49. ⟨hal-00734562⟩

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