A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity

Y. Xia (1) , M. Wang (1) , O. Demaria , J. Tang , P. Rocchi , F. Qu , J.L. Iovanna , L. Alexopoulou , Ling Peng (1)

1 CINaM - Centre Interdisciplinaire de Nanoscience de Marseille

A novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy

Domaines: Chimie

Y. Xia, M. Wang, O. Demaria, J. Tang, P. Rocchi, et al.. A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity. Journal of Medicinal Chemistry, 2012, 55 (11), pp.5642-5646. ⟨10.1021/jm300534u⟩. ⟨hal-00724325⟩