An alternative to the breeder's and Lande's equations.

Bahram Houchmandzadeh (1)

1 BIOP-LIPhy - BIOP - Fluctuations, Régulation et Evolution des Systèmes Vivants

The breeder's equation is a cornerstone of quantitative genetics and is widely used in evolutionary modeling. The equation which reads R=h^{2}S relates response to selection R (the mean phenotype of the progeny) to the selection differential S (mean phenotype of selected parents) through a simple proportionality relation. The validity of this relation however relies strongly on the normal (Gaussian) distribution of parent's genotype which is an unobservable quantity and cannot be ascertained. In contrast, we show here that if the fitness (or selection) function is Gaussian, an alternative, exact linear equation in the form of R'=j^{2}S' can be derived, regardless of the parental genotype distribution. Here R' and S' stand for the mean phenotypic lag behind the mean of the fitness function in the offspring and selected populations. To demonstrate this relation, we derive the exact functional relation between the mean phenotype in the selected and the offspring population and deduce all cases that lead to a linear relation between these quantities. These computations, which are confirmed by individual based numerical simulations, generalize naturally to the multivariate Lande's equation \Delta\mathbf{\bar{z}}=GP^{-1}\mathbf{S} .

Mots clés: quantitative genetics; breeder's equation; lande equation; phenotypic evolution; reponse to selection

Domaines: Génétique; Biophysique [physics.bio-ph]

Bahram Houchmandzadeh. An alternative to the breeder's and Lande's equations.. G3, 2014, 4(1) (1), pp.97-108. ⟨10.1534/g3.113.008433⟩. ⟨hal-00722308v3⟩