Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer.

Emilie Bertrand (1) , Cristine Gonçalves (2) , Ludivine Billiet (2) , Jean Pierre Gomez (2) , Chantal Pichon (2) , Hervé Cheradame (1) , Patrick Midoux (2) , Philippe Guégan (1)

1 LAMBE - Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement
2 CBM - Centre de biophysique moléculaire

A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes.

Domaines: Biochimie, Biologie Moléculaire

Emilie Bertrand, Cristine Gonçalves, Ludivine Billiet, Jean Pierre Gomez, Chantal Pichon, et al.. Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer.. Chemical Communications, 2011, 47 (46), pp.12547-12549. ⟨10.1039/c1cc15716g⟩. ⟨hal-00720539⟩