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Visualizing stages of cortical atrophy in progressive MCI from the ADNI cohort

Abstract : Amnestic mild cognitive impairment (MCI) is considered a condition where patients are at risk of developing clinically definite Alzheimer's disease (AD) with an annual conversion rate of approximately 15%. AD is characterized by progressive brain atrophy with major impact on the cerebral cortex and medial temporal lobe structures such as hippocampus. Understanding the structural pattern of cortical atrophy at different stages of MCI, before AD can be diagnosed, may help in patient monitoring and prognosis. In this study, we used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to calculate and visualize the cortical atrophy at different stages in patients who eventually converted to clinically definite AD.
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Submitted on : Tuesday, July 10, 2012 - 10:37:06 AM
Last modification on : Monday, December 20, 2021 - 4:50:10 PM
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  • HAL Id : hal-00716199, version 1



Simon Eskildsen, Vladimir Fonov, Pierrick Coupé, Louis Collins. Visualizing stages of cortical atrophy in progressive MCI from the ADNI cohort. Alzheimer's Association International Conference, Jul 2012, Vancouver, Canada. epub ahead of print. ⟨hal-00716199⟩



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