Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin

Sylvain Goutelle (1) , Laurent Bourguignon (1) , Roger W. Jelliffe (2) , John E. Conte (3) , Pascal Maire (1)

1 Université de Lyon
2 USC - University of Southern California
3 Department of Epidemiology & Biostatistics

There is a critical need for improved and shorter tuberculosis (TB) treatment. Current models of TB, while valuable, are poor predictors of the antibacterial effect of drugs . Mathematical models may be useful to overcome the limitations of traditional approaches in TB research. The objective of this study was to set up a prototype mathematical model of TB treatment by rifampin, based on pharmacokinetic, pharmacodynamic and disease submodels.

Mots clés: Tuberculosis; Mathematical model; Simulations; Pharmacokinetics; Pharmacodynamics; Disease modeling; Rifampin

Domaines: Sciences du Vivant [q-bio]

Sylvain Goutelle, Laurent Bourguignon, Roger W. Jelliffe, John E. Conte, Pascal Maire. Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin. Journal of Theoretical Biology, 2011, ⟨10.1016/j.jtbi.2011.05.013⟩. ⟨hal-00709543⟩