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Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin

Abstract : There is a critical need for improved and shorter tuberculosis (TB) treatment. Current models of TB, while valuable, are poor predictors of the antibacterial effect of drugs . Mathematical models may be useful to overcome the limitations of traditional approaches in TB research. The objective of this study was to set up a prototype mathematical model of TB treatment by rifampin, based on pharmacokinetic, pharmacodynamic and disease submodels.
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Submitted on : Tuesday, June 19, 2012 - 2:51:48 AM
Last modification on : Tuesday, October 22, 2019 - 6:48:02 PM

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Sylvain Goutelle, Laurent Bourguignon, Roger W. Jelliffe, John E. Conte, Pascal Maire. Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin. Journal of Theoretical Biology, Elsevier, 2011, ⟨10.1016/j.jtbi.2011.05.013⟩. ⟨hal-00709543⟩

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