Multi-resolution graph-based analysis of histopathological whole slide images: application to mitotic cell extraction and visualization

Vincent Roullier (1) , Olivier Lezoray (1) , Vinh Thong Ta (2) , Abderrahim Elmoataz (1)

1 Equipe Image - Laboratoire GREYC - UMR6072
2 LaBRI - Laboratoire Bordelais de Recherche en Informatique

n this paper, we present a graph-based multi-resolution approach for mitosis extraction in breast cancer histological whole slide images. The proposed segmentation uses a multi-resolution approach which reproduces the slide examination done by a pathologist. Each resolution level is analyzed with a focus of attention resulting from a coarser resolution level analysis. At each resolution level, a spatial refinement by label regularization is performed to obtain more accurate segmentation around boundaries. The proposed segmentation is fully unsupervised by using domain specific knowledge.

Domaines: Traitement des images [eess.IV]

Vincent Roullier, Olivier Lezoray, Vinh Thong Ta, Abderrahim Elmoataz. Multi-resolution graph-based analysis of histopathological whole slide images: application to mitotic cell extraction and visualization. Computerized Medical Imaging and Graphics, 2011, 35, pp.603-615. ⟨hal-00708976⟩