Isoquinoline derivatives via stepwise regioselective sp2 and sp3C-H bond functionalization

T. Boudiar (1, 2) , Z. Sahli (3) , B. Sundararaju (3) , M. Achard (3) , Z. Kabouche (2) , H. Doucet (3) , Christian Bruneau (3)

1 centre de recherche en biotechnologies
2 UMC - Université Frères Mentouri – Constantine 1 = Constantine 1 – Frères Mentouri University
3 ISCR - Institut des Sciences Chimiques de Rennes

Efficient and practically attractive stepwise ruthenium- and palladium-catalyzed regioselective C−H bond functionalizations were achieved to produce 4- substituted tetrahydroisoquinoline derivatives featuring various heteroaromatic substructures in moderate to good yields. Both ruthenium- and palladium-based catalytic processes generated nontoxic and easily separable side products.

Domaines: Catalyse

T. Boudiar, Z. Sahli, B. Sundararaju, M. Achard, Z. Kabouche, et al.. Isoquinoline derivatives via stepwise regioselective sp2 and sp3C-H bond functionalization. Journal of Organic Chemistry, 2012, 77, pp.3674-3678. ⟨10.1021/jo300237s⟩. ⟨hal-00698397⟩