LuxR dependent quorum sensing inhibition by N,N'-disubstituted imidazolium salts. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2011

LuxR dependent quorum sensing inhibition by N,N'-disubstituted imidazolium salts.

Résumé

Thirty N,N'-disubstituted imidazolium salts have been synthesized and evaluated as LuxR antagonists. Substitution on one of the imidazolium nitrogen atoms includes benzhydryl, fluorenyl or cyclopentyl substituent, and alkyl chains of various lengths on the second one. Most of these compounds displayed antagonist activity, with IC(50) reaching the micromolar range for the most active ones. The disubstituted imidazolium scaffold is thus shown to be a new pertinent pharmacophore in the field of AHL dependent QS inhibition.

Domaines

Chimie organique

Dates et versions

hal-00695863 , version 1 (10-05-2012)

Identifiants

Citer

Mohamad Sabbah, Laurent Soulère, Sylvie Reverchon, Y. Queneau, Alain Doutheau. LuxR dependent quorum sensing inhibition by N,N'-disubstituted imidazolium salts.. Bioorganic and Medicinal Chemistry, 2011, 19 (16), pp.4868-75. ⟨10.1016/j.bmc.2011.06.075⟩. ⟨hal-00695863⟩
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