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Possible role of calcium permselectivity in bone adaptation

Abstract : According to the core activity of calcium in the bone cellular expression, a new hypothesis linking calcium transport with the mechanical loading is proposed to explain the mechano-adaptation of bone tissue. Due to the piezoelectric coupling, the tensile and compressive areas of bone produce different electrical environments for the osteocytic cells that are embedded in the lacuno-canalicular porosity. This electrical asymmetry engenders a calcium enrichment-exclusion effect that strongly changes the calcium concentration in the lacuno-canalicular fluid and thus modifies the remodelling process. A bibliographic body of evidence supporting this idea is given and its experimental validation is suggested. (C) 2011 Elsevier Ltd. All rights reserved.
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Contributor : Thibault Lemaire Connect in order to contact the contributor
Submitted on : Tuesday, May 1, 2012 - 11:28:58 AM
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T. Lemaire, S. Naili. Possible role of calcium permselectivity in bone adaptation. Medical Hypotheses, Elsevier, 2012, 78 (3), pp.367--369. ⟨10.1016/j.mehy.2011.12.005⟩. ⟨hal-00692642⟩



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