Fragment-based design of small RNA binders: promising developments and contribution of NMR.

Roba Moumné (1, 2) , Marjorie Catala , Valéry Larue (3) , Laurent Micouin (4) , Carine Tisné (3)

1 SSFMB - Synthèse, Structure et Fonction de Molécules Bioactives
2 UPMC - Université Pierre et Marie Curie - Paris 6
3 LCRB - UMR 8015 - Laboratoire de cristallographie et RMN biologiques
4 SSMIP - Synthèse et structure de molécules d'interet pharmacologique

Fragment-based drug design has become increasingly popular over the last decade. We review here the use of this approach to design small RNA binders. In addition, we discuss the use of NMR to detect the binding of small molecules on RNA targets and to guide chemists in the design of compounds targeting RNA.

Domaines: Chimie organique

Roba Moumné, Marjorie Catala, Valéry Larue, Laurent Micouin, Carine Tisné. Fragment-based design of small RNA binders: promising developments and contribution of NMR.. Biochimie, 2012, 94 (7), pp.1607-1619. ⟨10.1016/j.biochi.2012.02.002⟩. ⟨hal-00692356⟩