Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate.

Abstract : A phthalocyanine-chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(II) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.
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https://hal.archives-ouvertes.fr/hal-00687926
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Submitted on : Monday, April 16, 2012 - 9:59:25 AM
Last modification on : Wednesday, May 22, 2019 - 4:24:06 PM

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  • HAL Id : hal-00687926, version 1

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Sinem Tuncel, Jérémie Fournier-Dit-Chabert, Florian Albrieux, Vefa Ahsen, Sylvie Ducki, et al.. Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate.. Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10, pp.1154-1157. ⟨hal-00687926⟩

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