Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2012

Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate.

Vefa Ahsen
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Sylvie Ducki
Fabienne Dumoulin
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Résumé

A phthalocyanine-chalcone conjugate has been designed to combine the vascular disrupting effect of chalcones with the photodynamic effect of phthalocyanines. This potential dual photodynamic and antiangiogenic agent was obtained by the condensation of a tetrahydroxylated non-peripherally substituted Zn(II) phthalocyanine with an amino chalcone converted into the corresponding activated isocyanate. The conjugate was fully characterized.
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Dates et versions

hal-00687926 , version 1 (16-04-2012)

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  • HAL Id : hal-00687926 , version 1

Citer

Sinem Tuncel, Jérémie Fournier-Dit-Chabert, Florian Albrieux, Vefa Ahsen, Sylvie Ducki, et al.. Towards dual photodynamic and antiangiogenic agents: design and synthesis of a phthalocyanine-chalcone conjugate.. Organic & Biomolecular Chemistry, 2012, 10, pp.1154-1157. ⟨hal-00687926⟩
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