Formal synthesis of TMC-69-6H via a one-pot enantioselective domino proline-mediated aldol/olefin homologation procedure

Sophie Vuong (1) , Nicolas Brondel (1) , Christophe Len (1) , Sébastien Papot (1) , Brigitte) Renoux (1)

1 OrgaSynth - Synthèse organique [E5 – IC2MP équipe 5]

Enantioselective synthesis of TMC-69-6H was accomplished from readily accessible pyridone derivative via a domino proline-mediated aldol reaction/olefin homologation, followed by tandem ring-closing and cross metathesis. (C) 2011 Elsevier Ltd. All rights reserved.

Domaines: Chimie organique; Autre; Chimie

Sophie Vuong, Nicolas Brondel, Christophe Len, Sébastien Papot, Brigitte) Renoux. Formal synthesis of TMC-69-6H via a one-pot enantioselective domino proline-mediated aldol/olefin homologation procedure. Tetrahedron, 2012, 68 (2), pp.433-439. ⟨10.1016/j.tet.2011.11.025⟩. ⟨hal-00682648⟩