Activation of 1,2-Keto Esters with Takemoto's Catalyst toward Michael Addition to Nitroalkenes

Wilfried Raimondi (1) , Olivier Baslé (1) , Thierry Constantieux (1) , Damien Bonne (1) , Jean Rodriguez (1)

1 STeRéO

When activated with Takemoto's catalyst, 1,2-keto esters constitute versatile nucleophiles in the Michael addition reaction with nitroalkenes affording synthetically valuable, optically active anti-adducts in very good yields and high enantiomeric excesses.

Mots clés: asymmetric organocatalysis; 2-keto esters; Michael addition; pronucleophiles; Takemoto's catalyst

Domaines: Chimie organique

Wilfried Raimondi, Olivier Baslé, Thierry Constantieux, Damien Bonne, Jean Rodriguez. Activation of 1,2-Keto Esters with Takemoto's Catalyst toward Michael Addition to Nitroalkenes. Advanced Synthesis and Catalysis, 2012, 354, pp.563-568. ⟨10.1002/adsc.201100739⟩. ⟨hal-00682117⟩