A. Van-heeckeren, J. Tscheikuna, R. Walenga, M. Konstan, and P. Davis, Infection on Weight Loss, Lung Mechanics, and Cytokines in Mice, American Journal of Respiratory and Critical Care Medicine, vol.161, issue.1, pp.271-279, 2000.
DOI : 10.1164/ajrccm.161.1.9903019

R. Vandivier, T. Richens, S. Horstmann, A. Decathelineau, and M. Ghosh, Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences, AJP: Lung Cellular and Molecular Physiology, vol.297, issue.4, 2009.
DOI : 10.1152/ajplung.00030.2009

M. Konstan, M. Schluchter, W. Xue, and P. Davis, Decline in Children with Cystic Fibrosis, American Journal of Respiratory and Critical Care Medicine, vol.176, issue.11, pp.1084-1089, 2007.
DOI : 10.1164/rccm.200702-181OC

L. Lands, R. Milner, A. Cantin, D. Manson, and M. Corey, High-Dose Ibuprofen in Cystic Fibrosis: Canadian Safety and Effectiveness Trial, The Journal of Pediatrics, vol.151, issue.3, pp.249-254, 2007.
DOI : 10.1016/j.jpeds.2007.04.009

C. Vaughan, M. Murphy, and B. Buckley, Statins do more than just lower cholesterol, The Lancet, vol.348, issue.9034, pp.1079-1082, 1996.
DOI : 10.1016/S0140-6736(96)05190-2

B. Leung, N. Sattar, A. Crilly, M. Prach, and D. Mccarey, A Novel Anti-Inflammatory Role for Simvastatin in Inflammatory Arthritis, The Journal of Immunology, vol.170, issue.3, pp.1524-1530, 2003.
DOI : 10.4049/jimmunol.170.3.1524

A. Mckay, B. Leung, I. Mcinnes, N. Thomson, and F. Liew, A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma, The Journal of Immunology, vol.172, issue.5, pp.2903-2908, 2004.
DOI : 10.4049/jimmunol.172.5.2903

M. Lindhom and J. Nilsson, Simvastatin stimulates macrophage interleukin-1?? secretion through an isoprenylation-dependent mechanism, Vascular Pharmacology, vol.46, issue.2, pp.91-96, 2007.
DOI : 10.1016/j.vph.2006.07.001

M. Ehrenstein, E. Jury, and C. Mauri, Statins for Atherosclerosis ??? As Good as It Gets?, New England Journal of Medicine, vol.352, issue.1, pp.73-75, 2005.
DOI : 10.1056/NEJMe048326

D. Ferro, S. Parrotto, S. Basili, C. Alessandri, and F. Violi, Simvastatin inhibits the monocyte expression of proinflammatory cytokines in patients with hypercholesterolemia, Journal of the American College of Cardiology, vol.36, issue.2, pp.427-431, 2000.
DOI : 10.1016/S0735-1097(00)00771-3

L. Björkhem-bergman, P. Bergman, J. Andersson, and J. Lindh, Statin Treatment and Mortality in Bacterial Infections ??? A Systematic Review and Meta-Analysis, PLoS ONE, vol.26, issue.5, p.10702, 2010.
DOI : 10.1371/journal.pone.0010702.s003

J. Keddissi, W. Younis, E. Chbeir, N. Daher, and T. Dernaika, The Use of Statins and Lung Function in Current and Former Smokers, Chest, vol.132, issue.6, pp.1764-1771, 2007.
DOI : 10.1378/chest.07-0298

J. Lee, D. Lee, E. Kim, K. Choe, and Y. Oh, Simvastatin Inhibits Cigarette Smoking???induced Emphysema and Pulmonary Hypertension in Rat Lungs, American Journal of Respiratory and Critical Care Medicine, vol.172, issue.8, pp.987-993, 2005.
DOI : 10.1164/rccm.200501-041OC

A. Zeki, L. Franzi, J. Last, and N. Kenyon, Simvastatin Inhibits Airway Hyperreactivity, American Journal of Respiratory and Critical Care Medicine, vol.180, issue.8, 2009.
DOI : 10.1164/rccm.200901-0018OC

J. Jacobson, J. Barnard, D. Grigoryev, S. Ma, and R. Tuder, Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury, AJP: Lung Cellular and Molecular Physiology, vol.288, issue.6, pp.1026-1032, 2005.
DOI : 10.1152/ajplung.00354.2004

H. Yao, L. Mao, and J. Zhu, PROTECTIVE EFFECTS OF PRAVASTATIN IN MURINE LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY, Clinical and Experimental Pharmacology and Physiology, vol.95, issue.9, pp.793-797, 2006.
DOI : 10.1016/S0014-2999(00)00870-0

T. Hartung, W. Doecke, D. Bundschuh, M. Foote, and F. Gantner, Effect of filgrastim treatment on inflammatory cytokines and lymphocyte functions*1, Clinical Pharmacology & Therapeutics, vol.66, issue.4, pp.415-424, 1999.
DOI : 10.1053/cp.1999.v66.a101210

A. Bjerre, B. Brusletto, E. Høiby, P. Kierulf, and P. Brandtzaeg, Plasma interferon-?? and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic Gram-positive septic shock, Critical Care Medicine, vol.32, issue.2, pp.433-438, 2004.
DOI : 10.1097/01.CCM.0000104950.52577.97

M. Ouagued, C. Martin-chouly, G. Brinchault, C. Leportier-comoy, and . Depincéa, The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-?? production in whole blood from COPD patients, Pulmonary Pharmacology & Therapeutics, vol.18, issue.1, pp.49-54, 2005.
DOI : 10.1016/j.pupt.2004.09.031

P. Gilligan, Microbiology of airway disease in patients with cystic fibrosis., Clinical Microbiology Reviews, vol.4, issue.1, pp.35-51, 1991.
DOI : 10.1128/CMR.4.1.35

J. Cazalis, C. Bodet, G. Gagnon, and D. Grenier, Doxycycline Reduces Lipopolysaccharide-Induced Inflammatory Mediator Secretion in Macrophage and Ex Vivo Human Whole Blood Models, Journal of Periodontology, vol.79, issue.9, pp.1762-1768, 2008.
DOI : 10.1902/jop.2008.080051

A. Bellanger, L. Millon, K. Khoufache, D. Rivollet, and I. Bièche, Aspergillus fumigatus germ tube growth and not conidia ingestion induces expression of inflammatory mediator genes in the human lung epithelial cell line A549, Journal of Medical Microbiology, vol.58, issue.2, pp.174-179, 2009.
DOI : 10.1099/jmm.0.005488-0
URL : https://hal.archives-ouvertes.fr/hal-00448417

C. Svanborg, G. Godaly, and M. Hedlund, Cytokine responses during mucosal infections: role in disease pathogenesis and host defence, Current Opinion in Microbiology, vol.2, issue.1, pp.99-105, 1999.
DOI : 10.1016/S1369-5274(99)80017-4

I. Kuwahara, E. Lillehoj, W. Lu, I. Singh, and Y. Isohama, Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-??B activation via EGFR transactivation in a lung epithelial cell line, AJP: Lung Cellular and Molecular Physiology, vol.291, issue.3, pp.407-416, 2006.
DOI : 10.1152/ajplung.00471.2005

N. Sturges, M. Wikström, K. Winfield, S. Gard, and S. Brennan, Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4, Pediatric Pulmonology, vol.56, issue.9, pp.883-889, 2010.
DOI : 10.1002/ppul.21230

A. Augarten, G. Paret, I. Avneri, H. Akons, and M. Aviram, Systemic inflammatory mediators and cystic fibrosis genotype, Clinical and Experimental Medicine, vol.4, issue.2, pp.99-102, 2004.
DOI : 10.1007/s10238-004-0044-1

S. Schmitt-grohé, C. Naujoks, J. Bargon, T. Wagner, and R. Schubert, Interleukin-8 in whole blood and clinical status in cystic fibrosis, Cytokine, vol.29, pp.18-23, 2005.

G. Kronborg, M. Hansen, M. Svenson, A. Fomsgaard, and N. Hoiby, Cytokines in sputum and serum from patients with cystic fibrosis and chronicpseudomonas aeruginosa infection as markers of destructive inflammation in the lungs., Pediatric Pulmonology, vol.133, issue.5, pp.292-297, 1993.
DOI : 10.1002/ppul.1950150506

J. Elborn, L. Nixon, S. Bell, and D. Shale, To the editor: On tumor necrosis factor ?? in CF, Pediatric Pulmonology, vol.146, issue.6, pp.411-412, 1994.
DOI : 10.1002/ppul.1950170615

S. Sagel and F. Accurso, Monitoring Inflammation in CF: Cytokines, Clinical Reviews in Allergy & Immunology, vol.23, issue.1, pp.41-57, 2002.
DOI : 10.1385/CRIAI:23:1:041

I. Langezaal, S. Coecke, and T. Hartung, Whole blood cytokine response as a measure of immunotoxicity, Toxicology in Vitro, vol.15, issue.4-5, pp.313-318, 2001.
DOI : 10.1016/S0887-2333(01)00028-5

L. Nixon, Y. B. Bell, S. Elborn, J. Shale, and D. , Circulating Immunoreactive Interleukin-6 in Cystic Fibrosis, American Journal of Respiratory and Critical Care Medicine, vol.157, issue.6, pp.1764-1769, 1998.
DOI : 10.1164/ajrccm.157.6.9704086

J. Larosa, J. He, and S. Vupputuri, Effect of Statins on Risk of Coronary Disease: A Meta-analysis of Randomized Controlled Trials, Survey of Anesthesiology, vol.44, issue.6, pp.2340-2346, 1999.
DOI : 10.1097/00132586-200012000-00024

M. Falagas, G. Makris, D. Matthaiou, and P. Rafailidis, Statins for infection and sepsis: a systematic review of the clinical evidence, Journal of Antimicrobial Chemotherapy, vol.61, issue.4, pp.774-785, 2008.
DOI : 10.1093/jac/dkn019

K. Takano, S. Yamamoto, K. Tomita, M. Takashina, and H. Yokoo, Successful Treatment of Acute Lung Injury with Pitavastatin in Septic Mice: Potential Role of Glucocorticoid Receptor Expression in Alveolar Macrophages, Journal of Pharmacology and Experimental Therapeutics, vol.336, issue.2, pp.381-390, 2010.
DOI : 10.1124/jpet.110.171462

D. Bont, N. Netea, M. Rovers, C. Smilde, T. Demacker et al., LPS-induced cytokine production and expression of LPS-receptors by peripheral blood mononuclear cells of patients with familial hypercholesterolemia and the effect of HMG-CoA reductase inhibitors, Atherosclerosis, vol.139, issue.1, pp.147-152, 1998.
DOI : 10.1016/S0021-9150(98)00074-4

F. Goldman, R. Hohl, J. Crabtree, K. Lewis-tibesar, and G. Koretzky, Lovastatin inhibits T-cell antigen receptor signaling independent of its effects on ras, Blood, vol.88, pp.4611-4619, 1996.

S. Niwa, T. Totsuka, and S. Hayashi, Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line, International Journal of Immunopharmacology, vol.18, issue.11, pp.669-675, 1996.
DOI : 10.1016/S0192-0561(96)00068-9

R. Terkeltaub, J. Solan, M. Barry, D. Santoro, and G. Bokoch, Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells, J Leukocyte Biol, vol.55, pp.749-755, 1994.

M. Horn, S. Knecht, F. Rushing, J. Birdsong, and C. Siddall, Simvastatin Inhibits Staphylococcus aureus Host Cell Invasion through Modulation of Isoprenoid Intermediates, Journal of Pharmacology and Experimental Therapeutics, vol.326, issue.1, pp.135-143, 2008.
DOI : 10.1124/jpet.108.137927
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482125

M. Chello, A. Anselmi, C. Spadaccio, G. Patti, and C. Goffredo, Simvastatin Increases Neutrophil Apoptosis and Reduces Inflammatory Reaction After Coronary Surgery, The Annals of Thoracic Surgery, vol.83, issue.4, pp.1374-1380, 2007.
DOI : 10.1016/j.athoracsur.2006.10.065

M. Fessler, S. Young, S. Jeyaseelan, J. Lieber, and P. Arndt, A Role for Hydroxy-Methylglutaryl Coenzyme A Reductase in Pulmonary Inflammation and Host Defense, American Journal of Respiratory and Critical Care Medicine, vol.171, issue.6, pp.606-615, 2005.
DOI : 10.1164/rccm.200406-729OC

X. Ou, B. Wang, F. Wen, Y. Feng, and X. Huang, Simvastatin attenuates lipopolysaccharide-induced airway mucus hypersecretion in rats, Chin Med J, vol.121, pp.1680-1687, 2008.

K. Sakoda, M. Yamamoto, Y. Negishi, J. Liao, and K. Node, Simvastatin Decreases IL-6 and IL-8 Production in Epithelial Cells, Journal of Dental Research, vol.85, issue.6, pp.520-523, 2006.
DOI : 10.1177/154405910608500608

B. Johnson, A. Iacono, A. Zeevi, K. Mccurry, and S. Duncan, Statin Use Is Associated with Improved Function and Survival of Lung Allografts, American Journal of Respiratory and Critical Care Medicine, vol.167, issue.9, pp.1271-1278, 2003.
DOI : 10.1164/rccm.200205-410OC

P. Kiener, P. Davis, J. Murray, S. Youssef, and B. Rankin, Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors, International Immunopharmacology, vol.1, issue.1, pp.105-118, 2001.
DOI : 10.1016/S0162-3109(00)00272-1

A. Corsini, M. Mazzotti, M. Raiteri, M. Soma, and G. Gabbiani, Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase, Atherosclerosis, vol.101, issue.1, pp.117-125, 1993.
DOI : 10.1016/0021-9150(93)90107-6

M. Shyamsundar, S. Mckeown, O. Kane, C. Craig, T. Brown et al., Simvastatin Decreases Lipopolysaccharide-induced Pulmonary Inflammation in Healthy Volunteers, American Journal of Respiratory and Critical Care Medicine, vol.179, issue.12, pp.1107-1114, 2009.
DOI : 10.1164/rccm.200810-1584OC

G. Földes, S. Von-haehling, D. Okonko, E. Jankowska, and P. Poole-wilson, Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure, International Journal of Cardiology, vol.124, issue.1, pp.80-85, 2008.
DOI : 10.1016/j.ijcard.2006.12.024

D. Zhao and C. Pothoulakis, Rho GTPases as therapeutic targets for the treatment of inflammatory diseases, Expert Opinion on Therapeutic Targets, vol.915, issue.2, pp.583-592, 2003.
DOI : 10.1161/01.RES.87.7.526

N. Kreiselmeier, N. Kraynack, D. Corey, and T. Kelley, Statin-mediated correction of STAT1 signaling and inducible nitric oxide synthase expression in cystic fibrosis epithelial cells, American Journal of Physiology - Lung Cellular and Molecular Physiology, vol.285, issue.6, pp.1286-1295, 2003.
DOI : 10.1152/ajplung.00127.2003

R. Rowntree and A. Harris, The Phenotypic Consequences of CFTR Mutations, Annals of Human Genetics, vol.10, issue.5, pp.471-485, 2003.
DOI : 10.1146/annurev.genet.29.1.777

O. Sullivan, B. Freedman, and S. , Cystic fibrosis, The Lancet, vol.373, issue.9678, pp.1891-1904, 2009.
DOI : 10.1016/S0140-6736(09)60327-5