Organocatalytic Synthesis of 1,2,3-Triazoles from Unactivated Ketones and Arylazides

Mokhtaria Belkheira (1, 2) , Douniazad El Abed (1) , Jean-Marc Pons (3) , Cyril Bressy (3)

1 Laboratoire de Réactivité et Chimie Fine
2 ISM2 - Institut des Sciences Moléculaires de Marseille
3 STeRéO

Organo-click reaction: A new and complementary method to Huisgen's metal-catalyzed triazole synthesis is described using unactivated ketones and arylazides as the substrates and proline as an organocatalyst. Dramatic acceleration was observed for this reaction using microwave activation and high regio- and chemoselectivities were obtained for a wide range of ketones and arylazides

Mots clés: cycloaddition; enamines; microwave chemistry; organocatalysis; proline; triazoles

Domaines: Chimie organique

Mokhtaria Belkheira, Douniazad El Abed, Jean-Marc Pons, Cyril Bressy. Organocatalytic Synthesis of 1,2,3-Triazoles from Unactivated Ketones and Arylazides. Chemistry - A European Journal, 2011, 17, pp.12917 - 12921. ⟨10.1002/chem.201102046⟩. ⟨hal-00678912⟩