Ultrasmall rigid particles as multimodal probes for medical applications.

François Lux (1) , Anna Mignot (1, 2, 3) , Pierre Mowat (1) , Cédric Louis (3) , Sandrine Dufort (3) , Claire Bernhard (4) , Franck Denat (4) , Frédéric Boschetti (5) , Claire Brunet (6) , Rodolphe Antoine (6) , Philippe Dugourd (6) , Sophie Laurent (7, 8) , Luce Vander Elst (7, 8) , Robert Muller (7, 8) , Lucie Sancey (9) , Véronique Josserand (9) , Jean-Luc Coll (9) , Vasile Stupar (10) , Emmanuel Barbier (10) , Chantal Rémy (10) , Alexis Broisat (11) , Catherine Ghezzi (11) , Géraldine Le Duc (12) , Stéphane Roux (13) , Pascal Perriat (2) , Olivier Tillement (1)

1 LPCML - Laboratoire de Physico-Chimie des Matériaux Luminescents
2 MATEIS - Matériaux, ingénierie et science [Villeurbanne]
3 Nano-H SAS
4 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
5 CheMatech - Macrocycle Design Technologies
6 LASIM - Laboratoire de Spectrométrie Ionique et Moléculaire
7 General, Organic and Biomedical Chemistry
8 NMR and Molecular Imaging Laboratory
9 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
10 ANTE-INSERM U836, équipe 5 - Neuro-imagerie fonctionnelle et métabolique
11 Radiopharmaceutiques biocliniques
12 ESRF - European Synchrotron Radiation Facility
13 UTINAM - Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213)

Ultrasmall but multifunctional: Rigid imaging particles that are smaller than 5 nm in size can be obtained in a top-down process starting from a core–shell structure (core=gadolinium oxide; shell=polysiloxane). They represent the first multifunctional silica-based particles that are sufficiently small to escape hepatic clearance and enable animal imaging by four complementary techniques

Domaines: Neurosciences [q-bio.NC]

François Lux, Anna Mignot, Pierre Mowat, Cédric Louis, Sandrine Dufort, et al.. Ultrasmall rigid particles as multimodal probes for medical applications.. Angewandte Chemie International Edition, 2011, 50 (51), pp.12299-303. ⟨10.1002/anie.201104104⟩. ⟨inserm-00658275⟩