Breathing Particles for Controlling Thermo-Sequential On/Off Drug Delivery

Anne-Claire Le Meur (1, 2) , Cyril Aymonier (3) , Valérie Héroguez (4, 5)

1 IDPS-Bertin Pharma
2 Bertin Technologies - Bertin Technologies
3 ICMCB - Institut de Chimie de la Matière Condensée de Bordeaux
4 LCPO - Laboratoire de Chimie des Polymères Organiques
5 Team 1 LCPO : Polymerization Catalyses & Engineering

Two for three: An original combination of two thermoresponsive polymers organized inside a single submicron particle is developed to release drug following a three-step process, which consists of a first spontaneous release at room temperature followed by two possible thermosensitive effects.

Mots clés: Polymers; Thermosensitive materials; Drug delivery; Nnanoparticles; Supercritical fluids

Domaines: Matériaux; Polymères

Anne-Claire Le Meur, Cyril Aymonier, Valérie Héroguez. Breathing Particles for Controlling Thermo-Sequential On/Off Drug Delivery. ChemPhysChem, 2012, 13 (3), pp.692-694. ⟨10.1002/cphc.201100677⟩. ⟨hal-00673143⟩