Dendritic Carrier Based on PEG: Design and Degradation of Acid-sensitive Dendrimer-like Poly(ethylene oxide)s

Xiaoshuang Feng (1) , Elliot L. Chaikof (2) , Christelle Absalon (3) , Carlos Drummond (4) , Daniel Taton (1, 5) , Yves Gnanou (1)

1 LCPO - Laboratoire de Chimie des Polymères Organiques
2 Harvard Univ, Sch Med - Dept Surg, BethIsrael Deaconess Med Ctr
3 ISM - Institut des Sciences Moléculaires
4 CRPP - Centre de recherches Paul Pascal
5 Team 1 LCPO : Polymerization Catalyses & Engineering

Degradable dendrimer-like PEO's were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 kg . mol(-1) was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (approximate to 2 kg . mol(-1)), as monitored by H-1 NMR, SEC, and MALDI-TOF mass spectrometry as well as by AFM.

Mots clés: biodegradable; branching; dendrimer; ketal; poly(ethylene oxide)

Domaines: Polymères

Xiaoshuang Feng, Elliot L. Chaikof, Christelle Absalon, Carlos Drummond, Daniel Taton, et al.. Dendritic Carrier Based on PEG: Design and Degradation of Acid-sensitive Dendrimer-like Poly(ethylene oxide)s. Macromolecular Rapid Communications, 2011, 32 (21), pp.1722-1728. ⟨10.1002/marc.201100459⟩. ⟨hal-00817490⟩