P. Bednarek and A. Osbourn, Plant-Microbe Interactions: Chemical Diversity in Plant Defense, Science, vol.324, issue.5928, pp.746-748, 2009.
DOI : 10.1126/science.1171661

B. Delobel and A. M. Grenier, Effect of non-cereal food on cereal weevils and tamarind pod weevil (Coleoptera: Curculionidae), Journal of Stored Products Research, vol.29, issue.1, pp.7-14, 1993.
DOI : 10.1016/0022-474X(93)90014-U

B. Delobel, A. M. Grenier, J. Gueguen, E. Ferrasson, and M. Mbaiguinam, Utilisation d'un polypeptide dérivé d'une albumine PA1b de légumineuse comme insecticide, 1998.

T. J. Higgins, P. M. Chandler, P. J. Randall, D. Spencer, L. R. Beach et al., Gene structure, protein structure, and regulation of the synthesis of a sulfur-rich protein in pea seeds, J. Biol. Chem, vol.261, pp.11124-11130, 1986.

F. Gressent, G. Duport, I. Rahioui, Y. Pauchet, P. Bolland et al., Biological Activity and Binding Site Characteristics of the PA1b Entomotoxin on Insects from Different Orders, Journal of Insect Science, vol.7, issue.12, pp.1-10, 2007.
DOI : 10.1673/031.007.1201

URL : https://hal.archives-ouvertes.fr/hal-00391325

K. R. Hancock, P. M. Ealing, and D. W. White, Idendification of sulphur-rich proteins which resist rumen degradation and are hydrolysed rapidly by intestinal proteases, British Journal of Nutrition, vol.25, issue.06, pp.855-863, 1994.
DOI : 10.1079/BJN19880083

D. Spencer, T. J. Higgins, M. Freer, H. Dove, and J. B. Coombe, Monitoring the fate of dietary proteins in rumen fluid using gel electrophoresis, British Journal of Nutrition, vol.66, issue.02, pp.241-247, 1988.
DOI : 10.1079/BJN19720092

I. Rahioui, C. Laugier, S. Balmand, P. Da-silva, Y. Rahbe et al., Toxicity, binding and internalization of the pea-A1b entomotoxin in Sf9 cells, Biochimie, vol.89, issue.12, pp.1539-1543, 2007.
DOI : 10.1016/j.biochi.2007.07.021

URL : https://hal.archives-ouvertes.fr/hal-00391507

F. Gressent, I. Rahioui, and Y. Rahbe, Characterization of a high-affinity binding site for the pea albumin 1b entomotoxin in the weevil Sitophilus, European Journal of Biochemistry, vol.60, issue.11, pp.2429-2435, 2003.
DOI : 10.1016/S0041-0101(98)00149-4

URL : https://hal.archives-ouvertes.fr/hal-00402185

T. Yamazaki, M. Takaoka, E. Katoh, K. Hanada, M. Sakita et al., A possible physiological function and the tertiary structure of a 4-kDa peptide in legumes, European Journal of Biochemistry, vol.253, issue.6, pp.1269-1276, 2003.
DOI : 10.1126/science.283.5409.1911

X. P. Dun, J. H. Wang, L. Chen, J. Lu, F. F. Li et al., Activity of the plant peptide aglycin in mammalian systems, FEBS Journal, vol.12, issue.Suppl., pp.751-759, 2007.
DOI : 10.1111/j.1742-4658.2006.05619.x

O. L. Franco, Peptide promiscuity: An evolutionary concept for plant defense, FEBS Letters, vol.79, issue.7, pp.995-1000, 2011.
DOI : 10.1016/j.febslet.2011.03.008

O. Carvalho-ade and V. M. Gomes, Plant defensins???Prospects for the biological functions and biotechnological properties, Peptides, vol.30, issue.5, pp.1007-1020, 2009.
DOI : 10.1016/j.peptides.2009.01.018

D. J. Craik, M. Cemazar, and N. L. Daly, The Chemistry and Biology of Cyclotides, ChemInform, vol.10, issue.31, pp.176-184, 2007.
DOI : 10.1002/chin.200731246

N. L. Daly and D. J. Craik, Bioactive cystine knot proteins, Current Opinion in Chemical Biology, vol.15, issue.3, pp.362-368, 2011.
DOI : 10.1016/j.cbpa.2011.02.008

A. M. Grenier, M. Mbaiguinam, and B. Delobel, Genetical analysis of the ability of the rice weevil Sitophilus oryzae (Coleoptera, Curculionidae) to breed on split peas, Heredity, vol.79, issue.1, pp.15-23, 1997.
DOI : 10.1038/hdy.1997.118

R. S. Norton and P. K. Pallaghy, The cystine knot structure of ion channel toxins and related polypeptides, Toxicon, vol.36, issue.11, pp.1573-1583, 1998.
DOI : 10.1016/S0041-0101(98)00149-4

C. Chouabe, V. Eyraud, P. Da-silva, I. Rahioui, C. Royer et al., New Mode of Action for a Knottin Protein Bioinsecticide: PEA ALBUMIN 1 SUBUNIT b (PA1b) IS THE FIRST PEPTIDIC INHIBITOR OF V-ATPase, Journal of Biological Chemistry, vol.286, issue.42, pp.36291-36296, 2011.
DOI : 10.1074/jbc.M111.281055

S. P. Muench, M. Huss, C. F. Song, C. Phillips, H. Wieczorek et al., Cryo-electron Microscopy of the Vacuolar ATPase Motor Reveals its Mechanical and Regulatory Complexity, Journal of Molecular Biology, vol.386, issue.4, pp.989-999, 2009.
DOI : 10.1016/j.jmb.2009.01.014

H. Wieczorek, K. W. Beyenbach, M. Huss, and O. Vitavska, Vacuolar-type proton pumps in insect epithelia, Journal of Experimental Biology, vol.212, issue.11, pp.1611-1619, 2009.
DOI : 10.1242/jeb.030007

H. Wieczorek, D. Brown, S. Grinstein, J. Ehrenfeld, and W. Harvey, Animal plasma membrane energization by proton-motive V-ATPases, BioEssays, vol.94, issue.8, pp.637-648, 1999.
DOI : 10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W

M. Toei, R. Saum, and M. Forgac, Regulation and Isoform Function of the V-ATPases, Biochemistry, vol.49, issue.23, pp.4715-4723, 2010.
DOI : 10.1021/bi100397s

Y. Watanabe, S. F. Barbashov, S. Komatsu, A. M. Hemmings, M. Miyagi et al., A Peptide that Stimulates Phosphorylation of the Plant Insulin-Binding Protein. Isolation, Primary Structure and cDNA Cloning, European Journal of Biochemistry, vol.167, issue.27, pp.167-172, 1994.
DOI : 10.1016/0005-2744(81)90106-6

C. Shang, H. Sassa, and H. Hirano, The role of glycosylation in the function of a 48-kDa glycoprotein from carrot, Biochemical and Biophysical Research Communications, vol.328, issue.1, pp.144-149, 2005.
DOI : 10.1016/j.bbrc.2004.12.166

K. Hanada, Y. Nishiuchi, and H. Hirano, Amino acid residues on the surface of soybean 4-kDa peptide involved in the interaction with its binding protein, European Journal of Biochemistry, vol.264, issue.12, pp.2583-2592, 2003.
DOI : 10.1021/bi00247a019

D. Silva, P. Rahioui, I. Laugier, C. Jouvensal, L. Meudal et al., Molecular Requirements for the Insecticidal Activity of the Plant Peptide Pea Albumin 1 Subunit b (PA1b), Journal of Biological Chemistry, vol.285, issue.43, pp.32689-32694, 2010.
DOI : 10.1074/jbc.M110.147199

URL : https://hal.archives-ouvertes.fr/hal-00591660

X. P. Dun, F. F. Li, J. H. Wang, and Z. W. Chen, The effect of pea albumin 1F on glucose metabolism in mice, Peptides, vol.29, issue.6, pp.891-897, 2008.
DOI : 10.1016/j.peptides.2008.01.013

Z. Hu, X. Dun, M. Zhang, H. Zhu, L. Xie et al., PA1b, a plant peptide, induces intracellular [Ca 2+ ] increase via Ca 2+ influx through the L-type Ca 2+ channel and triggers secretion, pancreatic beta cells. Sci. China C Life Sci, pp.285-291, 2007.

M. A. Graham, K. A. Silverstein, S. B. Cannon, and K. A. Vandenbosch, Computational Identification and Characterization of Novel Genes from Legumes, PLANT PHYSIOLOGY, vol.135, issue.3, pp.1179-1197, 2004.
DOI : 10.1104/pp.104.037531

K. A. Silverstein, W. A. Moskal, . Jr, H. C. Wu, B. A. Underwood et al., Small cysteine-rich peptides resembling antimicrobial peptides have been under-predicted in plants, The Plant Journal, vol.62, issue.2, pp.262-280, 2007.
DOI : 10.1111/j.1365-313X.2007.03136.x

P. M. Chandler, D. Spencer, P. J. Randall, and T. J. Higgins, Influence of Sulfur Nutrition on Developmental Patterns of Some Major Pea Seed Proteins and Their mRNAs, PLANT PHYSIOLOGY, vol.75, issue.3, pp.651-657, 1984.
DOI : 10.1104/pp.75.3.651

S. C. Ilgoutz, N. Knittel, J. M. Lin, S. Sterle, and K. R. Gayler, Transcription of genes for conglutin gamma and a leginsulin-like protein in narrow-leafed lupin, Plant Molecular Biology, vol.34, issue.4, pp.613-627, 1997.
DOI : 10.1023/A:1005868105651

R. L. Morton, A. J. Ellery, and T. J. Higgins, Downstream elements from the pea albumin 1 gene confer sulfur responsiveness on a reporter gene, Mol. Gen. Genet, vol.259, pp.309-316, 1998.

S. Louis, B. Delobel, F. Gressent, I. Rahioui, L. Quillien et al., Molecular and biological screening for insect-toxic seed albumins from four legume species, Plant Science, vol.167, issue.4, pp.705-714, 2004.
DOI : 10.1016/j.plantsci.2004.04.018

W. G. Taylor, P. G. Fields, and J. L. Elder, Insecticidal Components from Field Pea Extracts:?? Isolation and Separation of Peptide Mixtures Related to Pea Albumin 1b, Journal of Agricultural and Food Chemistry, vol.52, issue.25, pp.7491-7498, 2004.
DOI : 10.1021/jf030806t

W. G. Taylor, D. H. Sutherland, D. J. Olson, A. R. Ross, and P. G. Fields, Insecticidal Components from Field Pea Extracts:?? Sequences of Some Variants of Pea Albumin 1b, Journal of Agricultural and Food Chemistry, vol.52, issue.25, pp.7499-7506, 2004.
DOI : 10.1021/jf030807l

S. Louis, B. Delobel, F. Gressent, G. Duport, O. Diol et al., Broad screening of the legume family for variability in seed insecticidal activities and for the occurrence of the A1b-like knottin peptide entomotoxins, Phytochemistry, vol.68, issue.4, pp.521-535, 2007.
DOI : 10.1016/j.phytochem.2006.11.032

URL : https://hal.archives-ouvertes.fr/hal-00373359

A. Heitz, L. Chiche, D. Le-nguyen, and B. Castro, Proton 2D NMR and distance geometry study of the folding of Ecballium elaterium trypsin inhibitor, a member of the squash inhibitors family, Biochemistry, vol.28, issue.6, pp.2392-2398, 1989.
DOI : 10.1021/bi00432a009

T. A. Holak, D. Gondol, J. Otlewski, and T. Wilusz, Determination of the complete three-dimensional structure of the trypsin inhibitor from squash seeds in aqueous solution by nuclear magnetic resonance and a combination of distance geometry and dynamical simulated annealing, Journal of Molecular Biology, vol.210, issue.3, pp.635-648, 1989.
DOI : 10.1016/0022-2836(89)90137-X

N. L. Daly and D. J. Craik, Bioactive cystine knot proteins, Current Opinion in Chemical Biology, vol.15, issue.3, pp.362-368, 2011.
DOI : 10.1016/j.cbpa.2011.02.008

H. Kolmar, Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins, Current Opinion in Pharmacology, vol.9, issue.5, pp.608-614, 2009.
DOI : 10.1016/j.coph.2009.05.004

D. C. Ireland, R. J. Clark, N. L. Daly, and D. J. Craik, Isolation, Sequencing, and Structure???Activity Relationships of Cyclotides, Journal of Natural Products, vol.73, issue.9, pp.1610-1622, 2010.
DOI : 10.1021/np1000413

O. Saether, D. J. Craik, I. D. Campbell, K. Sletten, J. Juul et al., Elucidation of the Primary and Three-Dimensional Structure of the Uterotonic Polypeptide Kalata B1, Biochemistry, vol.34, issue.13, pp.4147-4158, 1995.
DOI : 10.1021/bi00013a002

D. Silva, P. Strzepa, A. Jouvensal, L. Rahioui, I. Gressent et al., A folded and functional synthetic PA1b: An interlocked entomotoxic miniprotein, Biopolymers, vol.358, issue.5, pp.436-444, 2009.
DOI : 10.1002/bip.21217

URL : https://hal.archives-ouvertes.fr/hal-00521878

B. L. Barbeta, A. T. Marshall, A. D. Gillon, D. J. Craik, and M. A. Anderson, Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae, Proc. Natl. Acad. Sci, pp.1221-1225, 2008.
DOI : 10.1073/pnas.0710338104

C. Jennings, J. West, C. Waine, D. Craik, and M. Anderson, Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis, Proc. Natl. Acad. Sci, pp.10614-10619, 2001.
DOI : 10.1073/pnas.191366898

A. Chagollalopez, A. Blancolabra, A. Patthy, R. Sanchez, and S. Pongor, A novel alpha-amylase inhibitor from Amaranth (Amaranthus hypocondriacus) seeds, J. Biol. Chem, vol.269, pp.23675-23680, 1994.

P. M. Ealing, K. R. Hancock, and D. W. White, Expression of the pea albumin 1 gene in transgenic white clover and tobacco, Transgenic Research, vol.8, issue.6, pp.344-354, 1994.
DOI : 10.1007/BF01976766

J. Petit, Etude Structure/Fonction d'une Albumine Entomotoxique de Type A1b du Pois Chez le riz: Application à la Protection Contre le Ravageur Sitophilus Oryzae, Ph.D. Dissertation, 2006.

S. Louis, Diversité Structurale et d'activité Biologique des Albumines Entomotoxiques de Type A1b des Graines de Légumineuses Available online, Ph.D. Dissertation, Institut National des Sciences Appliquées de Lyon, 2004.