Skip to Main content Skip to Navigation
Journal articles

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

Abstract : Regulation of tryptophan metabolism by indoleamine 2,3-dioxygenase (IDO) in dendritic cells (DCs) is a highly versatile modulator of immunity. In inflammation, interferon γ (IFN-γ) is the primary IDO inducer to prevent hyperinflammatory responses, yet the enzyme is also responsible for longer-term self-tolerance effects. Here we show that treatment of mouse plasmacytoid DCs (pDCs) with transforming growth factor β (TGF-β) conferred regulatory effects on IDO that were mechanistically separable from its enzymic activity. We reveal that IDO is involved in intracellular signaling events responsible for self-amplification and maintenance of a stably regulatory phenotype in pDCs. Thus IDO has a tonic, non-enzymic function that contributes to TGF-β-driven tolerance in non-inflammatory contexts.
Document type :
Journal articles
Complete list of metadatas

Cited literature [47 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-00664558
Contributor : Hal Peer <>
Submitted on : Tuesday, January 31, 2012 - 2:50:14 AM
Last modification on : Tuesday, January 31, 2012 - 2:50:14 AM
Long-term archiving on: : Wednesday, December 14, 2016 - 4:12:36 AM

File

PEER_stage2_10.1038%2Fni.2077....
Files produced by the author(s)

Identifiers

Collections

Citation

Ursula Grohmann, Maria Teresa Pallotta, Ciriana Orabona, Claudia Volpi, Maria Laura Laura Belladonna, et al.. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nature Immunology, Nature Publishing Group, 2011, ⟨10.1038/ni.2077⟩. ⟨hal-00664558⟩

Share

Metrics

Record views

344

Files downloads

746