Oral transmission of L-type bovine spongiform encephalopathy in primate model.

Nadine Frances (1) , Simon Nicot (2) , Sylvie Rouland (1) , Anne-Gaëlle Biacabe (2) , Isabelle Quadrio (3) , Armand Perret-Liaudet (3) , Thierry Baron (2) , Jean-Michel Verdier (1)

1 MMDN - Mécanismes moléculaires dans les démences neurodégénératives
2 Laboratoire de Lyon [ANSES]
3 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]

We report transmission of atypical L-type bovine spongiform encephalopathy to mouse lemurs after oral or intracerebral inoculation with infected bovine brain tissue. After neurologic symptoms appeared, transmissibility of the disease by both inoculation routes was confirmed by detection of disease-associated prion protein in samples of brain tissue.

Domaines: Neurobiologie

Nadine Frances, Simon Nicot, Sylvie Rouland, Anne-Gaëlle Biacabe, Isabelle Quadrio, et al.. Oral transmission of L-type bovine spongiform encephalopathy in primate model.. Emerging Infectious Diseases, 2012, 18 (1), pp.142-5. ⟨10.3201/eid1801.111092⟩. ⟨hal-00662793⟩