Optimization, continuation and lack of the one-step diphosphorylation reaction. Assay of modification of the tetraethyl(pyrrolidine-2,2-diyl)bisphosphonate

Gilles Olive (1) , Alain Jacques (2)

1 OPEP - Laboratoire Organo Phosphoré et Espèce Paramagnétique
2 LCS - Laboratoire de Chimie Structurale

The optimization of the one-step diphosphorylation reaction is reported. The synthesis of new a-aminobisphosphonates with four and six-membered rings and acyclic species with several substituents on the nitrogen and on the carbon atom bearing the two phosphorus atoms is described.

Domaines: Chimie organique

Gilles Olive, Alain Jacques. Optimization, continuation and lack of the one-step diphosphorylation reaction. Assay of modification of the tetraethyl(pyrrolidine-2,2-diyl)bisphosphonate. Phosphorus, Sulfur, and Silicon and the Related Elements, 2003, 178 (1), pp.33-46. ⟨hal-00660754⟩