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Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.

Abstract : The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.
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Rémy Dureau, Florence Robert-Gangneux, Jean-Pierre Gangneux, Caroline Nugier-Chauvin, Laurent Legentil, et al.. Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.. Carbohydrate Research, Elsevier, 2010, 345 (10), pp.1299-305. ⟨10.1016/j.carres.2010.02.020⟩. ⟨hal-00660320⟩



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