Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.

Rémy Dureau (1) , Florence Robert-Gangneux (2) , Jean-Pierre Gangneux (2) , Caroline Nugier-Chauvin (1) , Laurent Legentil (1) , Richard Daniellou (1) , Vincent Ferrières (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 SeRAIC - Signalisation et Réponses aux Agents Infectieux et Chimiques

The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.

Mots clés: UDP-furanoses; Leishmania; Hexofuranosides; Visceral leishmaniasis

Domaines: Biochimie, Biologie Moléculaire; Microbiologie et Parasitologie

Rémy Dureau, Florence Robert-Gangneux, Jean-Pierre Gangneux, Caroline Nugier-Chauvin, Laurent Legentil, et al.. Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.. Carbohydrate Research, 2010, 345 (10), pp.1299-305. ⟨10.1016/j.carres.2010.02.020⟩. ⟨hal-00660320⟩