Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.

Rémy Dureau; Florence Robert-Gangneux; Jean-Pierre Gangneux; Caroline Nugier-Chauvin; Laurent Legentil; Richard Daniellou; Vincent Ferrières

doi:10.1016/j.carres.2010.02.020

Journal articles

Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.

Rémy Dureau ¹ Florence Robert-Gangneux ² Jean-Pierre Gangneux ² Caroline Nugier-Chauvin ¹ Laurent Legentil ¹ Richard Daniellou ¹ Vincent Ferrières ¹

1 ISCR - Institut des Sciences Chimiques de Rennes

2 SeRAIC - Signalisation et Réponses aux Agents Infectieux et Chimiques

Abstract : The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite.

keyword : UDP-furanoses Leishmania Hexofuranosides Visceral leishmaniasis

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Biochemistry, Molecular Biology

Life Sciences [q-bio] / Microbiology and Parasitology

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https://hal.archives-ouvertes.fr/hal-00660320
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Last modification on : Thursday, January 14, 2021 - 11:27:59 AM

Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.

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Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania.

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