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Control of the PEO chain conformation on nanoparticles by adsorption of PEO-block-poly(l-lysine) copolymers and its significance on colloidal stability and protein repellency

Abstract : The physical adsorption of PEO(n)-b-PLL(m) copolymers onto silica nanoparticles and the related properties of poly(ethylene oxide) (PEO)-coated particles were studied as a function of the block copolymer composition. Copolymers adopt an anchor-buoy conformation at the particle surface owing to a preferential affinity of poly(l-lysine) (PLL) blocks with the silica surface over PEO blocks when a large excess of copolymer is used. The interdistance between PEO chains at particle surface is highly dependent on the size of PLL segments; a dense brush of PEO is obtained for short PLL blocks (DP = 10), whereas PEO chains adopt a so-called interacting "mushroom" conformation for large PLL blocks (DP = 270). The size of the PEO blocks does not really influence the copolymer surface density, but it has a strong effect on the PEO layer thickness as expected. Salt and protein stability studies led to similar conclusions about the effectiveness of a PEO layer with a dense brush conformation to prevent colloidal aggregation and protein adsorption. Besides, a minimal PEO length is required to get full stabilization properties; as a matter of fact, both PEO(45)-b-PLL(10) and PEO(113)-b-PLL(10) give rise to a PEO brush conformation but only the latter copolymer efficiently stabilizes the particles in the presence of salt or proteins.
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https://hal.archives-ouvertes.fr/hal-00641723
Contributor : Stéphane Toulin <>
Submitted on : Wednesday, November 16, 2011 - 3:00:24 PM
Last modification on : Wednesday, June 24, 2020 - 3:02:21 AM

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Stéphanie Louguet, Nicolas Guidolin, Gilles Sigaud, Etienne Duguet, Sébastien Lecommandoux, et al.. Control of the PEO chain conformation on nanoparticles by adsorption of PEO-block-poly(l-lysine) copolymers and its significance on colloidal stability and protein repellency. Langmuir, American Chemical Society, 2011, 27 (21), pp.12891-12901. ⟨10.1021/la202990y⟩. ⟨hal-00641723⟩

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