Ruthenium Diacetate-catalysed Oxidative Alkenylation of C-H Bonds in Air: Synthesis of Alkenyl N-Arylpyrazoles

Percia Beatrice Arockiam (1) , Cédric Fischmeister (1) , Christian Bruneau (1) , Pierre H. Dixneuf (1)

1 ISCR - Institut des Sciences Chimiques de Rennes

Ru(OAc)2(p-cymene) catalyses the directed dehydrogenative alkenylation of N-aryl pyrazoles by styrene and alkyl acrylates in the presence of a catalytic or stoichiometric amount of Cu(OAc)2*H2O in air; the acetic acid solvent plays a key role. With arene electron-donating groups, ruthenium-catalysed ortho-dialkenylation with alkyl acrylates can be obtained. A new method to generate the oxidative homocoupling of N-phenylpyrazole is provided with the Ru(OAc)2(p-cymene) catalyst.

Domaines: Catalyse

Percia Beatrice Arockiam, Cédric Fischmeister, Christian Bruneau, Pierre H. Dixneuf. Ruthenium Diacetate-catalysed Oxidative Alkenylation of C-H Bonds in Air: Synthesis of Alkenyl N-Arylpyrazoles. Green Chemistry, 2011, 13, pp.3075-3078. ⟨10.1039/c1gc15875a⟩. ⟨hal-00651998⟩