sp3 C-H bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines.

Basker Sundararaju (1) , Mathieu Achard (1) , Gangavaram V. M. Sharma (2) , Christian Bruneau (1)

1 ISCR - Institut des Sciences Chimiques de Rennes
2 IICT - CSIR Indian Institute of Chemical Technology

A selective C(3)-alkylation via activation/functionalization of sp(3) C-H bond of saturated cyclic amines was promoted by (arene)ruthenium(II) complexes featuring a bidentate phosphino-sulfonate ligand upon reaction with aldehydes. This highly regioselective sustainable transformation takes place via initial dehydrogenation of cyclic amines and hydrogen autotransfer processes.

Domaines: Catalyse

Basker Sundararaju, Mathieu Achard, Gangavaram V. M. Sharma, Christian Bruneau. sp3 C-H bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines.. Journal of the American Chemical Society, 2011, 133 (27), pp.10340-3. ⟨10.1021/ja203875d⟩. ⟨hal-00651981⟩